Transcription profiling of mouse telencephalon primary cultures from Xbp1 knockouts and wild-type controls

ABSTRACT: XBP1 is a transcription factor that is induced by unconventional splicing associated with endoplasmic reticulum stress and plays a role in development of liver and plasma cells. We previously reported that brain derived neurotrophic factor (BDNF) leads to splicing of XBP1 mRNA in neurites, and that XBP1 is required for BDNF-induced neurite extension and branching. To search for the molecular mechanisms of how XBP1 plays a role in neural development, comprehensive gene expression analysis was performed in primary telencephalic neurons obtained from Xbp1 knockout mice at embryonic day 12.5. By searching for the genes induced by BDNF in wild type neurons but this induction was reduced in Xbp1 knockout mice, we found that upregulation of three GABAergic markers, somatostatin (Sst), neuropeptid

ORGANISM(S): Mus musculus

SUBMITTER: Kazuya Iwamoto 

PROVIDER: E-GEOD-11322 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress