Transcriptional profiling of FeHm effects on Haemophilus influenzae R2866

ABSTRACT: Background: Haemophilus influenzae has an absolute aerobic growth requirement for heme and has developed multiple complex mechanisms to obtain this essential nutrient. Although an understanding of the heme acquisition mechanisms of H. influenzae is emerging, significant gaps remain to be elucidated. In a previous study we utilized H. influenzae strain Rd KW20 to demonstrate the utility of transcriptional profiling in defining the genes exhibiting altered transcription in response to environmental iron and heme levels. The current study expands upon those initial observations by determining the iron/heme regulons of two additional H. influenzae clinical isolates, i.e. the type b isolate 10810 and the nontypeable isolate R2866, to characterize the core iron/heme regulon of the species. Res

ORGANISM(S): Haemophilus influenzae R2866

SUBMITTER: Timothy VanWagoner 

PROVIDER: E-GEOD-11349 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress