GcrA depletion study (Caulobacter vibrioides)
Ontology highlight
ABSTRACT:
ORGANISM(S): Caulobacter vibrioides
SUBMITTER: Peter Brende
PROVIDER: E-GEOD-1135 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Oscillating global regulators control the genetic circuit driving a bacterial cell cycle.
Holtzendorff Julia J Hung Dean D Brende Peter P Reisenauer Ann A Viollier Patrick H PH McAdams Harley H HH Shapiro Lucy L
Science (New York, N.Y.) 20040415 5673
A newly identified cell-cycle master regulator protein, GcrA, together with the CtrA master regulator, are key components of a genetic circuit that drives cell-cycle progression and asymmetric polar morphogenesis in Caulobacter crescentus. The circuit drives out-of-phase temporal and spatial oscillation of GcrA and CtrA concentrations, producing time- and space-dependent transcriptional regulation of modular functions that implement cell-cycle processes. The CtrA/GcrA regulatory circuit controls ...[more]
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