Transcription profiling of mouse SCCVII murine cell line reveals irradiated stroma selects for invasive and metastatic tumoc cells

ABSTRACT: Radiotherapy is widely used to treat human cancer. Patients locally recurring after radiotherapy, however, have increased risk of metastatic progression and poor prognosis. The clinical management of post-radiation recurrences remains an unresolved issue. Tumors growing in pre-irradiated tissues have an increased fraction of hypoxic cells and are more metastatic, a condition known as tumor bed effect. Here we demonstrate that tumor cells growing in a pre-irradiated bed, or selected in vitro though repeated cycles of severe hypoxia, retain an invasive and metastatic capacities when returned to normoxia. HIF activity, while it facilitates metastatic spreading of tumors growing in a pre-irradiated bed, is not essential. Through gene expression profiling and gain and loss of function experimen

ORGANISM(S): Mus musculus

SUBMITTER: Mauro Delorenzi 

PROVIDER: E-GEOD-11357 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress