A Genomic Score Prognostic of Outcome in Trauma Patients

ABSTRACT: Physiological, anatomical, and clinical laboratory analytic scoring systems (APACHE, Injury Severity Score (ISS)) have been utilized, with limited success, to predict outcome following injury. We hypothesized that a peripheral blood leukocyte gene expression score could predict outcome, including multiple organ failure, following severe blunt trauma. Contributor: The Inflammation and the Host Response to Injury Large Scale Collaborative Research Program Keywords: expression profiles cRNA derived from whole blood leukocytes obtained within 12 hours of hospital admission provided gene expression data for the entire genome that were used to create a gene expression score for each patient. Expression profiles from healthy volunteers were averaged to create a reference gene expression profile

ORGANISM(S): Homo sapiens

SUBMITTER: IDDC Inflammation & the Host Response to Injury 

PROVIDER: E-GEOD-11375 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress