Candidate prostate cancer genes through comparative expression-profiling of seminal vesicle

ABSTRACT: BACKGROUND: Prostate cancer is the most frequently diagnosed cancer among men in the United States. In contrast, cancer of the seminal vesicle is exceedingly rare, despite that the prostate and seminal vesicle share similar histology, secretory function, androgen dependency, blood supply, and (in part) embryonic origin. We hypothesized that gene-expression differences between prostate and seminal vesicle might inform mechanisms underlying the higher incidence of prostate cancer. METHODS: Whole-genome DNA microarrays were used to profile gene expression of 11 normal prostate and 7 seminal vesicle specimens (including 6 matched pairs) obtained from radical prostatectomy. Supervised analysis was used to identify genes differentially expressed between normal prostate and seminal vesicle, an

ORGANISM(S): Homo sapiens

SUBMITTER: Jonathan Pollack 

PROVIDER: E-GEOD-11376 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress