Transcription profiling of human monocytes in familial combined hyperlipidemia and its modification by atorvastatin treatment

ABSTRACT: Introduction: The genetic origin of familial combined hyperlipidemia (FCH) is not well understood. We used microarray profiling of peripheral blood monocytes to search novel genes and pathways involved in FCH. Methods: Fasting plasma for determination of lipid profiles, inflammatory molecules, and adipokines was obtained and peripheral blood monocytes were isolated from male FCH patients basally and after 4 weeks of atorvastatin treatment. Sex-, age- and adiposity-matched controls were also studied. Gene expression profile was analyzed using Affymetrix Human Genome U133A 2.0 GeneChip arrays. Results: Analysis of gene expression by cDNA microarrays showed that 82 genes were differentially expressed in FCH monocytes compared to controls. Atorvastatin treatment modified the expression of 87

ORGANISM(S): Homo sapiens

SUBMITTER: Marta Alegret 

PROVIDER: E-GEOD-11393 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress