Transcription profiling of human mature oocytes and embryonic stem cells reveals overexpression of the proteasome pathway

ABSTRACT: The first week of human pre-embryo development is characterized by the induction of totipotency and then pluripotency. The understanding of this delicate process will have far reaching implication for in vitro fertilization and regenerative medicine. Human mature MII oocytes and embryonic stem (ES) cells are both able to achieve the feat of cell reprogramming towards pluripotency, either by somatic cell nuclear transfer or by cell fusion, respectively. Comparison of the transcriptome of these two cell types may highlight genes that are involved in pluripotency initiation. Therefore, based on a microarray compendium of 205 samples, produced in our laboratory or from public databases, we compared the gene expression profile of mature MII oocytes and human ES cells (hESC) to that of somatic t

ORGANISM(S): Homo sapiens

SUBMITTER: John De Vos 

PROVIDER: E-GEOD-11450 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress