Transcription profiling of rat hippocampus DG region after spatial learning training

ABSTRACT: A theoretical framework for the function of the medial temporal lobe system in memory defines differential contributions of the hippocampal subregions with regard to pattern recognition retrieval processes and encoding of new information. To investigate molecular programs of relevance, we designed a spatial learning protocol to engage a pattern separation function to encode new information. After background training, two groups of animals experienced the same new training in a novel environment, however only one group was provided spatial information and demonstrated spatial memory in a retention test. Global transcriptional analysis of the microdissected subregions of the hippocampus exposed a CA3 pattern that was sufficient to clearly segregate spatial learning animals from control. Indi

ORGANISM(S): Rattus norvegicus

SUBMITTER: Carlo Colantuoni 

PROVIDER: E-GEOD-11475 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress