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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of mouse hypothalamus, liver, kidney, ovary, and testes from male and female mice to assess sex specific differences in transcription

ABSTRACT: Sex Specific Transciption in Mouse Hypothalamus, Liver, Kidney, Ovary and Testis. For each somatic tissue there are 3 biological samples from different pools comprised of 10 animals for each sex each with a technical replicate. For each of the reproductive tissues there are 3 biological samples from different pools comprised of 10 animals with a technical replicate for each.

ORGANISM(S): Mus musculus

SUBMITTER: Joel Rozowsky

PROVIDER: E-GEOD-1148 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Major molecular differences between mammalian sexes are involved in drug metabolism and renal function.

Rinn John L JL Rozowsky Joel S JS Laurenzi Ian J IJ Petersen Petur H PH Zou Kaiyong K Zhong Weimin W Gerstein Mark M Snyder Michael M

Developmental cell 20040601 6

Many anatomical differences exist between males and females; these are manifested on a molecular level by different hormonal environments. Although several molecular differences in adult tissues have been identified, a comprehensive investigation of the gene expression differences between males and females has not been performed. We surveyed the expression patterns of 13,977 mouse genes in male and female hypothalamus, kidney, liver, and reproductive tissues. Extensive differential gene expressi ...[more]

PMID: 15177028

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