Transcription profiling of Bos taurus granulosa and theca cells during ovarian antral follicle development.

ABSTRACT: Coordinated interactions between ovarian granulosa and theca cells are required for female endocrine function and fertility. To elucidate these interactions the regulation of the granulosa and theca cell transcriptomes during bovine antral follicle development were investigated. Granulosa cells and theca cells were isolated from small (<5 mm), medium (5-10 mm), and large (>10 mm) antral bovine follicles. A microarray analysis of 24,000 bovine genes revealed that granulosa cells and theca cells each had gene sets specific to small, medium and large follicle cells. Transcripts regulated (i.e., minimally changed 1.5-fold) during antral follicle development for the granulosa cells involved 446 genes and for theca cells 248 genes. Only 28 regulated genes were common to both granulosa and theca

ORGANISM(S): Bos taurus

SUBMITTER: Michael Skinner 

PROVIDER: E-GEOD-11495 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress