Transcription profiling of mouse Gcn2 wild-type and knockout liver perfused with or without methionine

ABSTRACT: In eukaryotes, regulation of mRNA translation enables a fast, localized and finely tuned expression of gene products. Within the translation process, the first stage of translation initiation is most rigorously modulated by the actions of eukaryotic initiation factors (eIFs) and their associated proteins. These 11 eIFs catalyze the joining of the tRNA, mRNA and rRNA into a functional translation complex. Their activity is influenced by a wide variety of extra- and intracellular signals, ranging from global, such as hormone signaling and unfolded proteins, to specific, such as single amino acid imbalance and iron deficiency. Their action is correspondingly comprehensive, in increasing or decreasing recruitment and translation of most cellular mRNAs, and specialized, in targeting transla

ORGANISM(S): Mus musculus

SUBMITTER: An Dang Do 

PROVIDER: E-GEOD-11496 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress