Identification of histone codes and crosstalk in fission yeast

ABSTRACT: Aims: To map histone modifications with unprecedented resolution both globally and locus-specifically, and to link modification patterns to gene expression. Materials & methods: Using correlations between quantitative mass spectrometry and chromatin immunoprecipitation/microarray analyses, we have mapped histone post-translational modifications in fission yeast (Schizosaccharomyces pombe). Results: Acetylations at lysine 9, 18 and 27 of histone H3 give the best positive correlations with gene expression in this organism. Using clustering analysis and gene ontology search tools, we identified promoter histone modification patterns that characterize several classes of gene function. For example, gene promoters of genes involved in cytokinesis have high H3K36me2 and low H3K4me2, whereas the c

ORGANISM(S): Schizosaccharomyces pombe

SUBMITTER: Karl Ekwall 

PROVIDER: E-GEOD-11511 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress