E-GEOD-11512 - Gene expression changes during primate postnatal brain development

Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

Gene expression changes during primate postnatal brain development

ABSTRACT: In development, timing is of the utmost importance, and the timing of various developmental processes are often changed during evolution. During human evolution sexual maturation has been delayed relative to other primates and this may have played a critical role for both the increase of human brain size and the rise of human-specific cognitive traits . We measured the timing of gene expression changes in the brains of humans, chimpanzees, and rhesus macaques throughout postnatal development. Human, chimpanzee and rhesus macaque post-mortem brain samples from the dorsolateral prefrontal cortex region were collected. The caudate nucleus region was additionally sampled for humans. The age ranges of the individuals in all three species covered the respective species' postnatal maturation period from infancy to young adulthood. RNA extracted from the dissected tissue was hybridized to Affymetrix® U133-plus2.0 GeneChip® arrays.

ORGANISM(S): Macaca mulatta

SUBMITTER: Mehmet Somel

PROVIDER: E-GEOD-11512 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Transcriptional neoteny in the human brain.

Somel Mehmet M Franz Henriette H Yan Zheng Z Lorenc Anna A Guo Song S Giger Thomas T Kelso Janet J Nickel Birgit B Dannemann Michael M Bahn Sabine S Webster Maree J MJ Weickert Cynthia S CS Lachmann Michael M Pääbo Svante S Khaitovich Philipp P

Proceedings of the National Academy of Sciences of the United States of America 20090323 14

In development, timing is of the utmost importance, and the timing of developmental processes often changes as organisms evolve. In human evolution, developmental retardation, or neoteny, has been proposed as a possible mechanism that contributed to the rise of many human-specific features, including an increase in brain size and the emergence of human-specific cognitive traits. We analyzed mRNA expression in the prefrontal cortex of humans, chimpanzees, and rhesus macaques to determine whether ...[more]

PMID: 19307592

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