Identification of flap structure specific endonuclease 1 as a factor involved in LTM formation of aversive learning

ABSTRACT: We proposed that DNA recombination/repair processes play a role in memory formation. Here, we used microarray analysis of rat amygdala genes to identify possible DNA recombination/repair factors involved in memory consolidation of conditioned taste aversion (CTA). Among the genes that showed statistically significant differential expression, we identified fen-1, encoding a flap-structure specific DNA endonuclease. Amygdalar fen-1 mRNA induction was associated to the illness component of CTA, since it could be observed by the pairing of a flavor and gastrointestinal illness, by the illness itself, but not by the presentation of the flavor alone. No CTA related induction of fen-1 expression was observed in the insular cortex. Importantly, functional validation studies demonstrated that

ORGANISM(S): Rattus norvegicus

SUBMITTER: Sandra Pena de Ortiz 

PROVIDER: E-GEOD-11520 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress