Genome-wide inter-primate comparison of gene expression profiles in multiple tissues

ABSTRACT: Regulatory changes have long been hypothesized to play an important role in primate evolution. To identify adaptive regulatory changes in humans, we performed a genome-wide survey for genes whose regulation evolves under natural selection. To do so, we used a novel multi-species microarray to measure gene expression levels in livers, kidneys, and hearts from six humans, chimpanzees, and rhesus macaques. Using the multi-species microarray, we compared gene expression levels within and between species in three tissues: Livers, Kidneys (cortex) and Heart muscle. For each tissue, we hybridized RNA samples from 6 individuals from each of the three species, and preformed two technical replicates for each sample. The total number of arrays analyzed is therefore 108 (= 3 species X 3 tissues X 6 i

ORGANISM(S): Macaca mulatta

SUBMITTER: Ran Blekhman 

PROVIDER: E-GEOD-11560 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress