The responses of astrocytes stimulated by extracellular a-synuclein

ABSTRACT: Abnormal neuronal aggregation of a-synuclein is implicated in the development of Parkinson’s disease. Glial cells also show extensive a-synuclein pathology and are thought to contribute to disease progression. However, the mechanism that produces the glial a-synuclein pathology and the interaction between neurons and glia in the disease-inflicted microenvironment remain unknown. Here, we show that in neuronal cells misfolded a-synuclein proteins are selectively translocated into vesicles, leading to exocytosis of the aggregated forms. More importantly, our data demonstrate that astrocytes take up the neuron-derived a-synuclein aggregates and produce a-synuclein inclusions similar to the ones found in human brains. This uptake is paralleled by changes in the gene expression profile reflecti

ORGANISM(S): Rattus norvegicus

SUBMITTER: Seung-Jae Lee 

PROVIDER: E-GEOD-11574 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress