FAIRE-chip in MCF7 and LNCaP
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Jérôme Eeckhoute
PROVIDER: E-GEOD-11579 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Cell-type selective chromatin remodeling defines the active subset of FOXA1-bound enhancers.
Eeckhoute Jérôme J Lupien Mathieu M Meyer Clifford A CA Verzi Michael P MP Shivdasani Ramesh A RA Liu X Shirley XS Brown Myles M
Genome research 20090107 3
Selective activity of a specific set of enhancers defines tissue-specific gene transcription. The pioneer factor FOXA1 has been shown to induce functional enhancer competency through chromatin openings. We have previously found that FOXA1 is recruited to thousands of regions across the genome of a given cell type. Here, we monitored the chromatin structure at FOXA1 binding sites on a chromosome-wide scale using formaldehyde assisted isolation of regulatory elements (FAIRE). Surprisingly, we find ...[more]
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