Transcription profiling of mouse oocytes to investigate age-associated increase in aneuploidy and changes in gene expression.

ABSTRACT: An increase in the incidence of aneuploidy is well documented with increasing maternal age, in particular in human females. Remarkably, little is known regarding the underlying molecular basis for the age-associated increase in aneuploidy, which is a major source of decreased fertility in humans. Using mouse as a model system we find that eggs obtained from old mice (60-70 weeks of age) display a 6-fold increase in the incidence of hyperploidy as assessed by chromosome spreads. Expression profiling of transcripts in oocytes and eggs obtained from young and old mice reveals that approximately 5% of the transcripts are differentially expressed in oocytes obtained from old females when compared to oocytes obtained from young females (6-12 weeks of age) and that this fraction increases to appr

ORGANISM(S): Mus musculus

SUBMITTER: Hua Pan 

PROVIDER: E-GEOD-11667 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress