Transcription profiling of human pediatric meningococcal sepsis patients reveals dynamic changes in NK-cell and cytotoxic molecules

ABSTRACT: Objective. Meningococcal sepsis remains an important cause of childhood morbidity and mortality. Largely due to logistic complexities of research in young children with acute life-threatening disease, very little is known regarding differential expression kinetics and molecular regulation of immune response genes in leukocyte subsets. Materials and methods. In this prospective case-control study, six children with meningococcal sepsis were included. Blood was drawn at four time points (t=0, t=8, t=24 and t=72 h after admission to the paediatric intensive care unit). Blood was also collected from matched controls. Detailed immunophenotyping of leukocytes was performed; RNA isolated from whole blood, lymphocytes, monocytes, and granulocytes was used to perform Affymetrix micro-array gene ex

ORGANISM(S): Homo sapiens

SUBMITTER: Marieke Emonts 

PROVIDER: E-GEOD-11755 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress