Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

Bortezomib resistance in THP-1 cell line

ABSTRACT: Bortezomib is a proteasome inhibitor used in severel different hematological malignancies. Resistance to this drug is still poorly understood. In order get more insight in the resistance mechanism, we developed several bortezomib resistant subclones of the THP-1 monocytic/macrophage cell line. On these subclones expression arrays were performed. We performed expression array three different bortezomib resistant subclones of the THP-1 cell line. The resistant subclones were spotted against the parental THP-1 wildtype cell line.

ORGANISM(S): Homo sapiens

SUBMITTER: Serge Smeets

PROVIDER: E-GEOD-11771 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Molecular basis of bortezomib resistance: proteasome subunit beta5 (PSMB5) gene mutation and overexpression of PSMB5 protein.

Oerlemans Ruud R Franke Niels E NE Assaraf Yehuda G YG Cloos Jacqueline J van Zantwijk Ina I Berkers Celia R CR Scheffer George L GL Debipersad Kabir K Vojtekova Katharina K Lemos Clara C van der Heijden Joost W JW Ylstra Bauke B Peters Godefridus J GJ Kaspers Gertjan L GL Dijkmans Ben A C BA Scheper Rik J RJ Jansen Gerrit G

Blood 20080618 6

The proteasome inhibitor bortezomib is a novel anticancer drug that has shown promise in the treatment of refractory multiple myeloma. However, its clinical efficacy has been hampered by the emergence of drug-resistance phenomena, the molecular basis of which remains elusive. Toward this end, we here developed high levels (45- to 129-fold) of acquired resistance to bortezomib in human myelomonocytic THP1 cells by exposure to stepwise increasing (2.5-200 nM) concentrations of bortezomib. Study of ...[more]

PMID: 18565852

Dataset Information

Bortezomib resistance in THP-1 cell line

Publications

Molecular basis of bortezomib resistance: proteasome subunit beta5 (PSMB5) gene mutation and overexpression of PSMB5 protein.

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