Transcription profiling of Drosophila wild type and bap170;bap180 double mutant reveals two PBAP chromatin remodeling complex-specific subunits have distinct, redundant functions during development

ABSTRACT: Chromatin remodeling complexes control the availability of DNA binding sites to transcriptional regulators. Two distinct forms of the major SWI/SNF-related complex that have different activities in vitro can be distinguished by the presence of specific accessory subunits. In Drosophila, the core Brahma complex associates either with Osa to form the BAP complex, or with Bap170 and Bap180 to form the PBAP complex. Mutations affecting the core subunits have stronger developmental phenotypes than osa mutations; these differences could be due to PBAP complex activity . We have generated mutations in the genes encoding the PBAP-specific subunits Bap170 and Bap180 in order to study their functions in vivo. Bap180 is not essential for viability, but is required in ovarian follicle cells for normal

ORGANISM(S): Drosophila melanogaster

SUBMITTER: Jessica Treisman 

PROVIDER: E-GEOD-11825 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress