Transcription profiling of human fibroblast model of somitogenesis

ABSTRACT: Scoliosis is a common disorder, affecting one out of every twenty females. Some forms of scoliosis are congenital, resulting from disruptions in early spinal development. The spinal column is patterned during a cycling process called somitogenesis, and is the first musculoskeletal structure formed during development. Genes in the notch signaling pathway regulate somitogenesis, and display oscillatory expression in synchrony with somite formation. During somitogenesis, oscillatory expression of genes in the notch and wnt signaling pathways plays a key role in regulating segmentation. These oscillations in expression levels are elements of a species-specific developmental mechanism. The periodicity and components of the human clock have recently been described by our group (William et a

ORGANISM(S): Homo sapiens

SUBMITTER: Elizabeth Salomon 

PROVIDER: E-GEOD-11854 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress