Differential expression of 24,426 human alternative splicing events and predicted cis-regulation in 48 tissues

ABSTRACT: Alternative pre-messenger RNA splicing impacts development, physiology, and disease, but its regulation in humans is not well understood, partially due to the limited scale to which the expression of specific splicing events has been measured. We generated the first genome-scale expression compendium of human alternative splicing events using custom whole-transcript microarrays monitoring expression of 24,426 mutually exclusive alternative splicing event pairs in 48 diverse human samples. Over 11,700 genes and 9,500 splicing events were differentially expressed, providing a rich resource for studying splicing regulation. An unbiased, systematic screen of 21,760 4-mer to 7-mer words for cis-regulatory motifs identified 143 RNA 'words' enriched near regulated cassette exons, including six c

ORGANISM(S): Homo sapiens

SUBMITTER: Amit Kulkarni 

PROVIDER: E-GEOD-11863 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress