Children's Oncology Group Study 9906 for High-Risk Pediatric ALL

ABSTRACT: PAPER 1:"Identification of novel subgroups of high-risk pediatric precursor B acute lymphoblastic leukemia (B-ALL) by unsupervised microarray analysis: clinical correlates and therapeutic implications. A Children's Oncology Group (COG) study." ABSTRACT We examined gene expression profiles of pre-treatment specimens from 207 patients from the COG P9906 study to identify signatures of children with high risk B-precursor acute lymphoblastic leukemia (ALL) and to determine whether the resulting clusters are associated with either specific clinical features or treatment response characteristics. Four unsupervised clustering methods were utilized to classify patients into similar groups. The different clustering algorithms showed significant overlap in cluster membership. Two clus

ORGANISM(S): Homo sapiens

SUBMITTER: Maurice Murphy 

PROVIDER: E-GEOD-11877 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress