Transcription profiling of human normal brain aging reveals sexually dimorphic gene expression

ABSTRACT: Gene expression profiles were assessed in the hippocampus (HC), entorhinal cortex (EC), superior frontal gyrus (SG), and postcentral gyrus (PCG) across the lifespan of 63 cognitively intact individuals from 20-99 years old. New perspectives on the global gene changes that are associated with brain aging emerged, revealing two overarching concepts. First, different regions of the forebrain exhibited substantially different gene profile changes with age. For example, comparing equally powered groups, 5,029 probe sets were significantly altered with age (20-59 vs. 60-99) in the superior frontal gyrus, compared with 1,110 in the entorhinal cortex. Prominent change occurred in the 6th-7th decades across cortical regions, suggesting that this period is a critical transition point in brain ag

ORGANISM(S): Homo sapiens

SUBMITTER: Nicole Claudia Berchtold 

PROVIDER: E-GEOD-11882 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress