Transcription profiling of mouse wildtype and transgenic mice that expressed either human beta1-Arg389 and beta1-Gly389 receptors, or AC5 adenyl cyclase - differential cardiac gene regulation by Arg- and Gly389 polymorphic forms of the beta1-adrenergic receptor

ABSTRACT: The beta1-adrenergic receptor (beta1AR; ADRB1) polymorphism Arg 389Gly is located in an intracellular loop and is associated with distinct human and mouse cardiovascular phenotypes. To test the hypothesis that beta1-Arg389 and beta1-Gly389 alleles could differentially couple to pathways beyond that of classic Gs-adenylyl cyclase (AC)/cAMP signaling, we performed comparative gene expression profile analyses on hearts from wildtype and transgenic mice that expressed either human beta1-Arg389 and beta1-Gly389 receptors, or AC5 adenyl cyclase, sampling at an early age and stage, prior to the onset of pathologic features. We observed substantial overlap of dysregulated genes across all three transgenic heart models, consistent with a shared coupling to cAMP-dependent regulation of cardiac proce

ORGANISM(S): Mus musculus

SUBMITTER: Bruce Aronow 

PROVIDER: E-GEOD-11887 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress