Transcription profiling of mouse developing and adult cornea compared to the lens and tendon

ABSTRACT: The cornea continues to mature after birth to develop a fully functional, refractive and protective barrier tissue. Here we investigated the complex biological events underlying this process by profiling global genome-wide gene expression patterns of the immature postnatal day 10 and seven week-old adult mouse cornea. The lens and tendon were included in the study to increase the specificity of genes identified as up regulated in the corneal samples. Notable similarities in gene expression between the cornea and the tendon were in the mesenchymal extracellular matrix collagen (types I, III, V, VI) and proteoglycan (lumican, decorin and biglycan) genes. Expression similarities in the cornea and lens were limited to certain epithelial genes and the crystallins. Approximately 76 genes were ov

ORGANISM(S): Mus musculus

SUBMITTER: Shukti Chakravarti 

PROVIDER: E-GEOD-11900 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress