Transcription profiling of mouse experimental model of asthma reveals a possible role of paraoxonase-1 in asthma

ABSTRACT: Background: Several studies indicate that asthma is a polygenic disease, and its complexity originates from the interaction of an unknown number of genes with environmental factors. Objective: In this study we aimed to identify new genes, gene groups and pathways involved in the pathogenesis of experimental asthma. Methods: In an ovalbumin-induced murine model of asthma we applied microarray gene expression analysis of the lung at different time points in the asthmatic process. Advanced statistical methods were used to relate gene expression changes to cellular processes and to integrate our results into multiple levels of information available in public databases. Results: According to the observed marked neutrophil infiltration found early, at 4 hours after the first allergen challenge

ORGANISM(S): Mus musculus

SUBMITTER: Gergely Tolgyesi 

PROVIDER: E-GEOD-11911 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress