Identification of a subgroup of head and neck cancers lacking numerical chromosomal aberrations

ABSTRACT: ABSTRACT Two major subgroups of head and neck squamous cell carcinomas (HNSCC) are currently distinguished based on etiology and pattern of genetic alterations; tumors with biologically active human papillomavirus (HPV) and tumors without. It is at present unclear whether additional genetically distinct subgroups exist within HPV-negative HNSCC. Aim of this study is to genetically classify HNSCC without HPV involvement and to correlate the genetically defined classes to tumor and patient characteristics. By means of array comparative genomic hybridization (aCGH) we determined DNA copy number variation in thirty-nine HPV-negative, but further unselected HNSCC. Unsupervised analysis of aCGH data distinguished two genetic groups in HPV-negative HNSCC, one characterized by a low level of chrom

ORGANISM(S): Homo sapiens

SUBMITTER: Serge Smeets 

PROVIDER: E-GEOD-11929 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress