Copy Number Alterations in HNSCC with or without Oncogene Expressing Human Papillomavirus

ABSTRACT: Oncogene expressing human papillomavirus type 16 (HPV16) is found in a subset of head and neck squamous cell carcinomas (HNSCC). HPV16 drives carcinogenesis by inactivating p53 and pRb with the viral oncoproteins E6 and E7, reflected by a low level of mutations in TP53 and allelic loss at 3p, 9p and 17p, genetic changes frequently found in HNSCCs of non-viral etiology. We hypothesize that two pathways to HNSCC exist: one determined by HPV16 and one by environmental carcinogens. To define the critical genetic events in these two pathways, we now present a detailed genome analysis of HNSCC with and without HPV16 involvement by employing high resolution micro-array comparative genomic hybridization. Four regions showed alterations in HPV-negative tumors that were absent in HPV-positive tumors

ORGANISM(S): Homo sapiens

SUBMITTER: Serge Smeets 

PROVIDER: E-GEOD-11931 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress