Transcription profiling of mouse laminin alpha 2 chain deficient animals vs wild type

ABSTRACT: Mutations in the gene encoding laminin a2 chain cause congenital muscular dystrophy, MDC1A. In skeletal muscle, laminin a2 chain binds at least two receptor complexes; the dystrophin-glycoprotein complex and integrin a7b1. To gain insight into the molecular mechanisms underlying this disorder, we performed gene expression profiling of laminin a2 chain deficient mouse limb muscle. One of the down-regulated genes encodes a protein called calcium and integrin binding protein 2 (Cib2) whose expression and function is unknown. However, the closely related Cib1 has been reported to bind integrin aIIb and may be involved in outside-in-signaling in platelets. Since Cib2 might be a novel integrin a7b1 binding protein in muscle, we have studied Cib2 expression in the developing and adult mouse. Cib2

ORGANISM(S): Mus musculus

SUBMITTER: Mattias Carl Häger 

PROVIDER: E-GEOD-12049 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress