Transcription profiling of Drosophila msl21 male larvae reveals MSL2 is required for upregulation of male X chromosome but not for expression of autosomal genes

ABSTRACT: Drosophila males double transcription of their single X chromosome to equalize X-linked gene expression with females, which carry two X chromosomes. Increased transcription requires the Male-Specific Lethal (MSL) complex. The MSL2 protein is essential component of the MSL complex. MSL2 is the only protein that is strictly limited to males. MSL2 together with MSL1 forms the core of the MSL complex. The global effect of msl2 mutation on gene expression was measured by microarray analysis. We found that expression of the X chromosome was decreased in msl21 male larvae, supporting the involvement of MSL2 in the up-regulation of X-linked genes. However, there was no change in expression of 4th chromosomal and heterochromatic genes. This finding is broadly comparable to reports of reduced X chro

ORGANISM(S): Drosophila melanogaster

SUBMITTER: Satya Kiran Koya 

PROVIDER: E-GEOD-12054 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress