A role for Multidrug Resistance Protein 4 (MRP4; ABCC4) in human Dendritic Cell migration.

ABSTRACT: The capacity of dendritic cells (DC) to migrate from peripheral organs to lymph nodes (LN) is an important event in the initiation of a T cell-mediated immune response. Previously it was shown that the ATP-binding cassette (ABC) transporters P-glycoprotein (P-gp; ABCB1) and the 2 multidrug resistance protein 1 (MRP1; ABCC1) play a role in both human and murine DC migration. Here we show that a more recently discovered family-member, MRP4 (ABCC4) is expressed on both epidermal and dermal human skin DC and contributes to the migratory capacity of DC. Pharmacological inhibition of MRP4 activity or down-regulation through RNAi in DC resulted in reduced migration of DC from human skin explants and of in vitro generated Langerhans cells. The responsible MRP4 substrate remains to be identified as

ORGANISM(S): Homo sapiens

SUBMITTER: jean-pierre gillet 

PROVIDER: E-GEOD-12089 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress