Array based miRNA Profiling of Clear Cell Renal Cell Cance

ABSTRACT: MicroRNAs (miRNAs) are short single stranded RNAs that are associated with gene regulation at the transcriptional and translational level. Changes in their expression were found in a variety of human cancers. Because of the lack of corresponding data in clear renal cell carcinoma (ccRCC) we have performed genome-wide expression profiling of miRNAs using microarray analysis and quantification of specific miRNAs by TaqMan real-time RT-PCR. Matched malignant and non-malignant tissue samples from two independent 12 ccRCC sets were profiled. The microassay-based experiments identified 14 overexpressed and 20 downregultaed miRNAs in malignant samples. Expression in ccRCC tissue samples compared to matched non-malignant samples measured by RT-PCR was increased by 2.7 to 28fold for the hsa-mir-16,

ORGANISM(S): Homo sapiens

SUBMITTER: Kristiansen Glenn 

PROVIDER: E-GEOD-12105 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress