Chemoprevention of the hepatocarcinogenesis by celecoxib

ABSTRACT: Microarray analysis is a useful methodology to identify target genes modulated by anticancer drugs. Here, celecoxib effect on gene expression profiles was evaluated in the modified resistant hepatocyte model. Animals subjected to carcinogenic treatment were fed with diet containing 1500 ppm of celecoxib. Two schemes of celecoxib administration were designed. In the progression protocol, celecoxib was administrated between days 18 and 25 post-cancer initiation, a total of 8 celecoxib treatment days, when well established preneoplastic lesions starts to appear. In the initiation protocol, celecoxib was administrated from one week before until 25 days after of cancer initiation, a total of 32 celecoxib treatment days. A rat group was subjected only to the carcinogenic treatment as cancer posi

ORGANISM(S): Rattus norvegicus

SUBMITTER: Adriana Marquez-Quiñones 

PROVIDER: E-GEOD-12112 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress