R. conorii transcriptional response within inoculation eschar battlefield

ABSTRACT: Rickettsia conorii, the causative agent of the MSF is transmitted to humans by the bite of infected ticks Rhipicephalus sanguineus. The skin thus constitutes an important barrier for the entry and propagation of R. conorii. Given this, analysis of the survival strategies used by the bacterium within infected skin is critical for our understanding of rickettsiosis. Here, we report the first genome-wide analysis of R. conorii gene expression from infected human skin biopsies. Our data showed that R. conorii exhibit a striking transcript signature that was remarkably conserved across patients, regardless of genotype. The expression profiles obtained using custom Agilent microarrays were validated by quantitative RT-PCR. Within eschars, approximately 15% (n = 211) of the total predicted R. con

ORGANISM(S): Rickettsia conorii

SUBMITTER: HUYGHE Antoine 

PROVIDER: E-GEOD-12130 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress