Colonic tissues from an acute TNBS-induced colitis model in SJL mice.
Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Antonie Zwiers
PROVIDER: E-GEOD-12139 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Increased expression of the tight junction molecule claudin-18 A1 in both experimental colitis and ulcerative colitis.
Zwiers Antonie A Fuss Ivan J IJ Leijen Suzanne S Mulder Chris J CJ Kraal Georg G Bouma Gerd G
Inflammatory bowel diseases 20081201 12
<h4>Background</h4>We previously identified a major quantitative trait locus (qtl) on mouse chromosome 9 (Tnbs1) that confers resistance/susceptibility to trinitrobenzene sulfonic acid (TNBS) induced colitis. Here we wanted to identify possible candidate genes in this locus.<h4>Methods</h4>We applied micro-array technology and identified claudin-18 as a plausible candidate gene in the Tnbs1 region. Subsequently we studied the expression profile of this gene by means of RT-PCR in resistant and su ...[more]
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