Gene expression profiles in zebrafish brain after acute exposure to domoic acid at symptomatic and asymptomatic doses

ABSTRACT: Domoic acid (DA) is a neuroexcitatory amino acid that is naturally produced by some marine diatom species of the genus Pseudo-nitzschia. Ingestion of DA-contaminated seafood by humans results in a severe neurotoxic disease known as amnesic shellfish poisoning (ASP). Clinical signs of ASP include seizures and neuronal damage from activation of AMPA and kainate receptors. However, the impacts of DA exposure at levels below those known to induce outward signs of neurobehavioral exicitotoxicity have not been well characterized. To further understand the mechanisms of neurotoxic injury associated with DA exposure, we examined the transcriptome of whole brains from zebrafish (Danio rerio) receiving intracoelomic (IC) DA at both symptomatic and asymptomatic doses. A majority of zebrafish e

ORGANISM(S): Danio rerio

SUBMITTER: Richard Beyer 

PROVIDER: E-GEOD-12140 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress