Transcription profiling of human thyroid follicles after stimulation of type I Interferon system by double-stranded RNA

ABSTRACT: Although viral infection is thought to be associated with subacute thyroiditis and probably with autoimmune thyroid disease, possible changes in thyroid function during the prodromal period of infection or subclinical infection remain largely unknown. Recently, it was shown that pathogen-associated molecular patterns stimulate Toll-like receptors (TLR) and activate innate immune responses by producing type I interferons (IFN). Using a human thyroid follicle culture system, in which de novo synthesized thyroid hormones are released into the culture medium under physiological concentrations of hTSH, we studied the effects of polyinosinic-polycytidylic acid (Poly(I:C)), a chemical analog of viral double-stranded RNA (dsRNA), on TSH-induced thyroid function. Thyrocytes expressed ligand

ORGANISM(S): Homo sapiens

SUBMITTER: Kanji Sato 

PROVIDER: E-GEOD-12154 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress