Transcription profiling of human frozen tumor biopsies from diffuse large cell lynohoma patients reveals mutations of multiple genes deregulate the NF-kB pathway in diffuse large B cell lymphoma

ABSTRACT: Diffuse large B-cell lymphoma (DLBCL), the most common form of lymphoma in adulthood, comprises multiple biologically and clinically distinct subtypes including germinal center B cell-like (GCB) and activated B cell like (ABC) DLBCL. Gene expression profile studies have shown that its most aggressive subtype, ABC-DLBCL, is associated with constitutive activation of the NF-kB transcription complex. However, except for a small fraction of cases, it remains unclear whether NF-kB activation in these tumors represents an intrinsic program of the tumor cell of origin or a pathogenetic event. Here we show that >50% of ABC-DLBCL and a smaller fraction of GCB-DLBCL carry somatic mutations at multiple genes, including negative (TNFAIP3/A20) and positive (CARD11, TRAF2, TRAF5, MAP3K7/TAK1 and TNFRSF1

ORGANISM(S): Homo sapiens

SUBMITTER: Laura Pasqualucci 

PROVIDER: E-GEOD-12195 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress