Transcription profiling of human lung fibroblasts (HLF) treated with Cr(VI) a carcingogen in the presence of PTP to investigate the effect of protein tyrosine phosphatases inhibition on changes in gene expression

ABSTRACT: Although the consequences of genotoxic injury include cell cycle arrest and apoptosis, cell survival responses after genotoxic injury can produce intrinsic death-resistance and contribute to the development of a transformed phenotype. Protein tyrosine phosphatases (PTPs) are integral components of key survival pathways, and are responsible for their inactivation, while PTP inhibition is are often associated with enhanced cell proliferation. Our aim was to elucidate signaling events that modulate cell survival after genotoxin exposure. Diploid human lung fibroblasts (HLF) were treated with Cr(VI) (as Na2CrO4), a well known human respiratory carcinogen that induces a wide spectrum of DNA damage, in the presence and absence of a broad-range PTP inhibitor, sodium orthovanadate. Notably, PTP in

ORGANISM(S): Homo sapiens

SUBMITTER: DONG-SOON BAE 

PROVIDER: E-GEOD-12205 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress