Transcription profiling of mouse 3 wild-type and 3 Crtc1 knockouts reveals the Creb1 coactivator Crtc1 is required for energy balance and fertility

ABSTRACT: The adipocyte-derived hormone leptin maintains energy balance by acting on hypothalamic leptin receptors (Leprs) that trigger the signal transducer and activator of transcription 3 (Stat3). Although disruption of Lepr-Stat3 signaling promotes obesity in mice, other features of Lepr function, such as fertility, seem normal, pointing to the involvement of additional regulators. Here we show that the cyclic AMP responsive elementâ??binding protein-1 (Creb1)-regulated transcription coactivator-1 (Crtc1) is required for energy balance and reproductionâ??Crtc1-/- mice are hyperphagic, obese and infertile. Hypothalamic Crtc1 was phosphorylated and inactive in leptin-deficient ob/ob mice; leptin administration increased amounts of dephosphorylated nuclear Crtc1. Dephosphorylated Crtc1 stimulated e

ORGANISM(S): Mus musculus

SUBMITTER: Marc Montminy 

PROVIDER: E-GEOD-12209 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress