Gene expression profiling indicates inflammatory pathways involved in IUGR due to placental insufficiency

ABSTRACT: Intrauterine growth restriction (IUGR) represents a major obstetric challenge with perinatal complications and a risk factor of developing disease in adult life. Placental insufficiency is one of the common features accompanying IUGR. The aim of this study was to evaluate global placental gene expression profile in IUGR compared to normal pregnancies. Placental samples were collected by eight IUGR pregnancies with placental insufficiency ascertained by Doppler and eight healthy controls. A 30K Human Genome Survey Microarray v.2.0 (Applied Biosystems) was used to evaluate global gene expression profile. Principal component analysis showed good separation in terms of gene expression patterns between the groups. Pathway analysis with Bonferroni correction for multiple testing

ORGANISM(S): Homo sapiens

SUBMITTER: Ruth Paulssen 

PROVIDER: E-GEOD-12216 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress