Genetic architecture of murine skin inflammation and tumor susceptibility

ABSTRACT: Gene expression in self-renewing epithelial tissues is controlled by cis- and trans-activating regulatory factors that mediate responses to exogenous agents capable of causing tissue damage, infection, inflammation, or tumorigenesis. We used network construction methods to analyze the genetic architecture of gene expression in normal mouse skin in a cross between tumor-susceptible Mus musculus and tumor-resistant Mus spretus. We demonstrate that gene expression motifs representing different constituent cell types within the skin such as hair follicle cells, haematopoietic cells, and melanocytes are under separate genetic control. Motifs associated with inflammation, epidermal barrier function and proliferation are differentially regulated in mice susceptible or resistant to tumor developm

ORGANISM(S): Mus musculus

SUBMITTER: David Quigley 

PROVIDER: E-GEOD-12248 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress