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Unknown,Transcriptomics,Genomics,Proteomics

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Global effects of 2-methoxyestradiol on smooth muscle cell hyperproliferation and vascular remodeling in atherosclerosis

ABSTRACT: We used microarrays to detail transcriptional changes in cultured human smooth muscle cells in response to acute and chronic 2-methoxyestradiol treatment 2-ME, an endogenous metabolite. of estradiol, not only exerts cytotoxic effects on cancer cells but it also protects against multiple proliferative disorders, including atherosclerosis and injury-induced intimal thickening Keywords: treatment vs. control Human aortic smooth muscle cells cultures with/without 2-methoxyestradiol (acute/chronic treatment)

ORGANISM(S): Homo sapiens

SUBMITTER: Michael Zaugg

PROVIDER: E-GEOD-12261 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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