Transcription profiling of human bone marrow and trabecular bone derived osteogenic cells - 3

ABSTRACT: The aim of this study was to describe the gene expression patterns related to the differentiation and mineralization of bone-forming cells, including activation and/or repression of osteogenic or non-osteogenic pathways, remodeling of cell architecture, cell adhesion, cell communication, and assembly of extracellular matrix. The study implied patient selection, tissue collection, isolation and culture of human marrow stromal cells (hMSC) and osteoblasts (hOB), and characterization of bone-forming cells. RNA samples were collected at defined time points, in order to understand the regulation of gene expression during the processes of cell differentiation/mineralization that occur during bone repair. Transcriptome analysis was performed by using the Affymetrix GeneChip microarray technology

ORGANISM(S): Homo sapiens

SUBMITTER: Lourdes Osaba 

PROVIDER: E-GEOD-12266 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress