Age-related behaviors have distinct transcriptional profiles in C. elegans

ABSTRACT: There has been a great deal of interest in identifying potential biomarkers of aging (Butler et al. 2004). Biomarkers of aging would be useful to predict potential vulnerabilities in an individual that may arise well before they are chronologically expected, due to idiosyncratic aging rates that occur between individuals. Prior attempts to identify biomarkers of aging have often relied on the comparisons of long-lived animals to a wild-type control (Dhahbi et al. 2004). However, the effect of interventions in model systems that prolong lifespan (such as single gene mutations, or caloric restriction) can sometimes be difficult to interpret due to the manipulation itself having multiple unforeseen consequences on physiology, unrelated to aging itself (Gems et al. 2002; Partridge & Gems 2006)

ORGANISM(S): Caenorhabditis elegans

SUBMITTER: Simon Melov 

PROVIDER: E-GEOD-12290 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress