Transcription profiling of rat gastrocnemius muscles from male animals to assess the effects of testosterone on dexamethasone-induced changes in gene expression

ABSTRACT: Glucocorticoids are a well recognized and common cause of muscle atrophy. Glucocorticoid-induced atrophy can be prevented by testosterone, but the molecular mechanisms underlying such protection have not been described. Thus, the global effects of testosterone on dexamethasone-induced changes in gene expression were evaluated in rat gastrocnemius muscle using Affymetrix 230_2 DNA microarrays. Gene expression was analyzed after 7 days administration of dexamethasone, dexamethasone plus testosterone, or vehicle. Effects of these agents on weights of gastrocnemius muscles from these animals has been reported (1. Zhao W, Pan J, Zhao Z, Wu Y, Bauman WA, and Cardozo CP. Testosterone protects against dexamethasone-induced muscle atrophy, protein degradation and MAFbx upregulation. J Steroid Bi

ORGANISM(S): Rattus norvegicus

SUBMITTER: christopher cardozo 

PROVIDER: E-GEOD-12296 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress