Transcription profiling of mouse normal lymphoid progenitors and MLL-AF4 leukemic lymphoblasts

ABSTRACT: We created a mouse model where conditional expression of physiologic levels of an Mll-AF4 fusion oncogene induces development of acute lymphoblastic (ALL) or acute myeloid leukemias (AML). Immunophenotypic and gene expression analysis of the ALL cells demonstrated bone marrow replacement with B-precursor cells which express a gene expression profile that has significant overlap with profiles in human MLL-rearranged ALL. Experiment Overall Design: Total RNA from normal pro-B, pre-B, immature B and mature B lymphocytes, and from leukemic pre-B cells was isolated and hybridized to Affymetrix expresison microarrays.

ORGANISM(S): Mus musculus

SUBMITTER: Madeleine Lemieux 

PROVIDER: E-GEOD-12310 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress